By X. Ingvar. Virginia Union University. 2018.
Malignant Lymphomas 314 Hematology This group of diseases is divided into Hodgkin’s disease and non-Hodgkin’s lymphomas purchase 20mg cialis sublingual fast delivery erectile dysfunction pills images. In many patients generic 20 mg cialis sublingual otc erectile dysfunction medication otc, the disease is localized initially to a single peripheral lymph node region and its subsequent progression is by contiguity within the lymphatic system. After a variable period of containment within the lymph nodes, 315 Hematology the natural progression of the disease is to disseminate to involve non-lymphatic tissue. It has bimodal age incidence, one peak in young adults (age 20-30 years) and a second after the age of 50. In developed counties the ratio of young adults to child cases and of nodular sclerosing disease to other types is increased. Tuberculosis may occur • Patients with bone disease may show hypercalcaemia, hypophosphataemia and increased levels of serum alkaline phosphatase. Laboratory findings • A Normochromic, normocytic anemia is usual but auto-immune hemolytic anemia may also occur. Multiple Myeloma Multiple myeloma (myelomatosis) is a neoplastic monoclonal proliferation of bone marrow plasma cells, characterized by lytic bone lesions, plasma cell accumulation in the bone marrow, and the presence of monoclonal protein in the serum and urine. Immunological testing shows these cells to be monoclonal B cells and to express the same 319 Hematology immunoglobulin heavy and light chains as the serum monoclonal protein. These disorders are closely related to each other; transitional forms occur and, in many patients, an evolution from one entity into another occurs during the course of the disease. Polycythemia vera Polycythemia (erythrocytosis) refers to a pattern of blood cell changes that includes an increase in hemoglobin above 17. In polycythemia vera (polycythemia rubra vera), the increase in red cell volume is caused by endogenous myeloproliferation. The stem cell origin of the defect is suggested in many patients by an over production of granulocytes and platelets as well as of red cells. Clonal cytogenetic abnormalities may occur, but there is no single characteristic change • Blood viscosity is increased • Plasma urate is often increased • Circulating erythroid progenitors are increased and grow in vitro independently of added erythropoietin. Essential thrombocythemia Megakaryocyte proliferation and overproduction of platelets is the dominant feature of this condition; there is sustained increase in platelet count above normal (400x109/l). Splenic enlargement is frequent in the early phase but splenic atrophy due to platelets blocking the splenic mirocirculation is seen in some patients. Laboratory findings • Abnormal large platelets and megakaryocyte fragments may be seen in the blood film. Myelofibrosis Myelofibrosis, one of the myeloproliferative diseases, is the gradual replacement of the bone marrow by connective tissue. Patients will typically have an enlarged spleen and liver, (hepatosplenomegaly), and examination of the blood cells will show "teardrop cells". There is an increase in circulating stem cells associated with the establishment of extramedullary hemopoiesis. Laboratory findings • Anemia is usual but a normal or increased hemoglobin level may be fond in some patients • The white cell and platelet counts are frequently high at the time of presentation. Trephine biopsy may show a hypercellular marrow with an increase in reticulin-fibre pattern; in other patients there is an increase in intercellular substance and variable collagen deposition. Introduction Leucocyte cytochemistry encompasses the techniques used to identify diagnostically useful enzymes or other substances in the cytoplasm of hemopoietic cells. These techniques are particularly useful for the characterization of immature cells in the acute myeloid leukemias, and the identification of maturation 328 Hematology abnormalities in the myeloproliferative disorders. The use of cytochemistry to characterize lymphoproliferative disorders has been largely superseded by immunological techniques. The results of cytochemical tests should always be interpreted in relation to Romanowsky stains and immunological techniques. Control blood or marrow slides should always be stained in parallel to assure the quality of the staining. The principal uses of cytochemistry are: • To characterize the blast cells in acute leukemias as myeloid.
Differential Diagnosis: Aneurysmal bone cyst cialis sublingual 20 mg with mastercard impotence from steroids, Benign Fibrous histiocytoma and aggressive chondromyxoid fibroma order cialis sublingual 20mg line erectile dysfunction wikihow. Excision in toto is ideal if the bone involved is expendable (like lower ulna, proximal fibula). In instances like lower radius, excision and reconstruction using proximal fibula is practiced. In weight bearing bones like distal femur or proximal tibia, when the the bone is totally destroyed, resection arthrodesis (Enneking procedure) is ideal if the patient belongs lower socioeconomic group. But if the patient belongs to higher strata where the load demands are less, excision and custom mega prosthesis may be practiced. In fungating cases or after repeated recurrences, an amputation may be the last resort. Differential Diagnosis: Early lesions are difficult to diagnose unless one has high index of suspicion. Any pain in the metaphyseal region following a minor injury and disproportionate to the injury or if the pain is slowly increasing day by day after minor injury and especially without fever should lead the clinician to suspect this sinister disease. Prevention: Genetic engineering is under trial to prevent the lesion in children who are genetically prone to suffer. In late cases pain preceding a spindle shaped swelling in the metaphysic of long bone must give suspicion of osteosarcoma. In cases of late presentation where tumour excision is not feasible a course of chemotherapy is followed by amputation of the limb – chemotherapy is continued. Introduction: Chondrosarcoma is a malignant bone tumor arising from chondroblasts. The lesion may arise de novo (primary chondrosarcoma) or there may be malignant transformation of an existing benign cartilaginous lesion - osteochondroma / enchondroma (secondary chondrosarcoma). Differential Diagnosis: Non aggressive lesions may be mistaken for benign tumours especially Fibrous Dysplasia. Prevention: Secondary chondrosarcomata may be prevented by proper treatment of primary cartilaginous lesion. Recent fast growth and onset of pain in a primary cartilaginous lesion should make one suspect secondary Chondrosarcoma b) Investigations: x-ray. Primary or secondary chondrosarcomata of the limb girdle may be difficult to treat surgically but excision and reconstruction may be tried depending on the situation. Custom made prostheses may be tried for chondrosarcomata of proximal humerus and femur if the lesions are intracompartmental. Introduction: A malignant bone tumour where the cell of origin is uncertain; usually occurring in the diaphyses of children. Differential Diagnosis: Osteomyelitis is a major competitor for diagnosis not only clinically but also radiological and histological. Fever points a finger at osteomyelitis but acute diaphyseal osteomyelitis is very uncommon. After an initial course of chemotherapy, wherever feasible, the tumour is resected and reconstruction done (appropriate surgery). For a recurrence of the tumour radiotherapy is preferred since the recurrence is from cells which are resistant to chemotherapy given earlier. Introduction: It is a malignant tumour of the marrow elements where plaslymacytes multiply cancerously in an elderly individual. Differential Diagnosis: The main contender is osteoporosis with compression fractures; Multiple metastases especially from prostate in males and breast in females should be thought of; Osteomalacia in late adulthood and Fibromyalgia syndrome are also to be differentiated. Calcium, Phosphorus, Alkaline phosphatase, Bone marrow examination (sternal puncture), serum protein electrophoresis 123 c) Treatment: Chemotherapy and cortisones 16) Name of condition: Malignant bone tumour – Metastatic Bone Tumours I. It is important to note that symptoms due to the primary disease are often lacking and only the secondary deposits cause symptoms. After suspecting a metastatic deposit, after x-ray examination patient has to be referred to a metro level hospital. For a pathological fracture (or an impending fracture), curettage of the lesion, filling with bone cement and internal fixation preferably with an intramedullary nail is palliative and gives comfort for the rest of the life.
All the open sections of these cartilages are at the back so that the esophagus can bulge into this section during swallowing discount cialis sublingual 20 mg with amex erectile dysfunction differential diagnosis. The right bronchus is considerably larger in diameter than the left and extends downward in a more vertical direction buy 20 mg cialis sublingual with amex impotence 30s. Each bronchus enters the lung at a notch or 298 Human Anatomy and Physiology depression called the hilus or hilum. The Lungs The lungs are the organs in which external respiration takes place through the extremely thin and delicate lung tissues. The two lungs, set side by side in the thoracic cavity, are constructed in the following manner: Each bronchus enters the lung at the hilus and immediately subdivides. Because the subdivision of the bronchi resembles the branches of a tree, they have been given the common name bronchial tree. The bronchi subdivide again and again, forming progressively smaller divisions, the smallest of which are called bronchioles. The bronchi contain small bits of cartilage, which give firmness to the walls and serve to hold 299 Human Anatomy and Physiology Figure 10-2. In the bronchioles there is no cartilage at all; what remains is mostly smoothly muscle, which is under the control of the autonomic nervous system. At the end of each of the smallest subdivisions of the bronchial tree, called terminal bronchioles, is a cluster of air sacs, resembling a bunch of grapes. This very thin wall provides easy passage for the gases entering and leaving the blood as it circulates through millions of tiny capillaries of the alveoli. Certain cells in the alveolar wall produce surfactant, a substance that prevents the alveoli from collapsing by reducing the surface tension (“pull”) of the fluids that line them. Because of the many air spaces, the lung is light in weight; normally a piece of lung tissue dropped into a glass of water will float. In the lungs bl9od passes through the capillaries around the alveoli, where the gas exchange takes place. The portion of the pleura that is attached to the chest wall is called parietal pleura, while the portion that is reflected onto the surface of the lung is called visceral pleura. The pleural cavity around the lungs is an air-tight space with a partial vacuum, which causes the pressure in this space to be less than atmospheric pressure. Because the pressure inside the lungs is higher than that in the surrounding pleural cavity, the lungs tend to remain inflated. The region between the lungs, the mediastinum, contains the heart, great blood vessels, esophagus, trachea, and lymph nodes. Physiology of Respiration Pulmonary Ventilation Ventilation is the movement of air into and out of the lungs, as in breathing. The contraction and relaxation of the diaphragm cause a piston-like downward motion that result in an increase in the vertical dimension of the chest. The rib cage is also moved upward and outward by contraction of the external intercostals muscles and, during exertion, by contraction of other muscles of the neck and chest. During quiet breathing, the movement of the diaphragm accounts for most of the increase in thoracic volume. In exhalation, the passive phase of breathing, the muscles of respiration relax, allowing the ribs and diaphragm to return to their original positions. During forced exhalation, the internal intercostals muscles and the muscles of the abdominal wall contracts, pulling the bottom of the rib cage in and down. Air Movement Air enters the respiratory passages and flows through the ever-dividing tubes of the bronchial tree. As the air traverses this passage, it moves more and more slowly through the great number of bronchial tubes until there is virtually no forward flow as it reaches the alveoli. Here the air moves by diffusion, which soon equalizes any differences in the amounts of gases present. Each breath causes relatively little change in the gas composition of the alveoli, but normal continuous breathing ensures the presence of adequate oxygen and the removal of carbon dioxide. Table 17-1 Breathing Volumes Volume Definition Average value Tidal volume The amount of air moved into or out 500 cc of the lungs in quiet, relaxed breathing Vital capacity The volume of air that can be 4800 cc expelled from the lungs by maximum exhalation following maximum inhalation Residual volume The volume of air that remains in the 1200 cc lungs after maximum exhalation Total lung The total volume of air that can be 6000 cc capacity contained in the lungs after maximum inhalation Functional The amount of air remaining in the 2400 cc residual capacity lungs after normal exhalation Regulation of respiration Regulation of respiration is a complex process that must keep pace with moment-to-moment changes in cellular oxygen requirements and carbon dioxide production.
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